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Sodium zirconium cyclosilicate
CAS No. 17141-74-1
Sodium zirconium cyclosilicate( —— )
Catalog No. M37191 CAS No. 17141-74-1
Sodium zirconium cyclosilicate (UXSi-9) is a novel selective cation exchanger and a K+ binder that can be used to remove excess K+ from the body and can be used in the treatment of hyperkalemia.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameSodium zirconium cyclosilicate
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NoteResearch use only, not for human use.
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Brief DescriptionSodium zirconium cyclosilicate (UXSi-9) is a novel selective cation exchanger and a K+ binder that can be used to remove excess K+ from the body and can be used in the treatment of hyperkalemia.
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DescriptionSodium zirconium cyclosilicate is an orally administered, non-absorbed, novel, inorganic microporous zirconium silicate compound, is a highly selective cation exchanger that selectively removes excess K+ in vivo. Sodium zirconium cyclosilicate can be used in research of chronic kidney disease (CKD).
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In VitroSodium zirconium cyclosilicate (ZS-9) is an inorganic cation exchange crystalline compound that has a high capacity to selectively entrap monovalent cations, specifically excess K+ and ammonium ions. Sodium zirconium cyclosilicatehas the exchange capacities for the divalent ions Ca2+ and Mg2+ are below 0.05 mEq/g, and a >25-fold selectivity for K+ over either Ca2+ or Mg2+.
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In VivoSodium zirconium cyclosilicate (ZS-9; 2-6 g/kg; p.o.; daily, for 5 d) is a recovery in feces of Sprague-Dawley rats and can efficient uptake and removal of potassium ions.Animal Model:Sprague-Dawley rats Dosage:2, 4, and 6 g/kg Administration:Oral administration; daily, for 5 days Result:Had 99% fecal recovery in rats.Uptake and removal of potassium ions in a dose-dependent manner.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number17141-74-1
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Formula Weight365.46
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Molecular FormulaNa2O9Si3Zr
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Purity>98% (HPLC)
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Solubility——
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SMILES[O-][Si]1(O[Si]([O-])(O[Si]([O-])(O1)[O-])[O-])[O-].[Na+].[Zr+4].[Na+]
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Stavros F, et, al. Characterization of structure and function of ZS-9, a K+ selective ion trap. PLoS One. 2014 Dec 22;9(12):e114686.?
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